History of the department

The Department of Pathological Physiology was founded in 1918, that is 2 years after the opening of the Ekaterinoslav Medical Institute. At that time, the department consisted of only one room in the territory of the “Zemsky hospital” - now the hospital named after I.I. Mechnikov. The founder of the department and its first head was Professor Anton I. Talyantsev (1918-1928), who got a higher education at Moscow University. There he began working as an assistant at the department of general and experimental pathology under the guidance of Professor A. B. Fochta. Anton I. Talyantsev devoted himself to the study of diseases of the cardiovascular system.

In 1892 he defended his dissertation for the degree of Doctor of Medical Sciences. In 1918, he was offered to position of head the Department of General and Experimental Pathology at the Ekaterinoslav Medical Institute. Where he developed a technique for modeling the blockage of coronary artery branches by introducing into the dissected carotid artery to the ostium aortae of a long bent probe with lateral holes, placing there a suspension of sedentar and rapeseed etc., which significantly pushed medicine towards the development of methods for diagnosing and treating coronary artery lesions. From 1918 to 1928, members of the department published 7 scientific works on the violation of local and general blood circulation and influence of changes in the functions of the pancreas on carbohydrate metabolism.

It is important to note that when Professor A.I. Talyaltsev came to the department, only a theoretical course was taught there, and under his leadership practical classes began to be held. In 1929, with the participation of the professor, the first practical training manual for students was published. One and a half years after his last lecture, given in 1928, Professor A.I. Talyanev died. He was remembered as person who has extreme simplicity and cordiality to both his students and colleagues.

In 1928, according to the results of the competition, Professor Fyodor M. Brikker (1928-1942), representative of the Kharkov School of Pathology, was elected to the position of head the department. At first, the main attention of the department staff was focused on the disturbance of carbohydrate, fat, protein and gas metabolism and their dynamics during the inflammatory process. Professor F. M. Brikker received research materials on this topic together with A. Charney, F. Supovitsky and J. Lazaris. The data from these studies are considered an important contribution to the study of inflammation. The next area of ​​research was the influence of some chemical agents on the body. The results were successful and were included in a specially published scientific collection, which was devoted to anti-chemical protection.

After that, the attention of the department in research activities shifted to the research of experimental therapy of tumors. Experimental data were presented in the antitumor immunity collection. F. M. Bricker was appointed deputy director for research. Over the course of several pre-war years, he raised the level of the department to a sufficiently high level, united various departments in joint issues and helped many young scientists to issue scientific works.
In the war years, the department was merged with Stavropol and evacuated to Stavropol. For two and a half years, colleagues from both institutions dealt with of defense issues, as well as with malignant tumors. In 1942, the Gestapo killed most of the staff of the Institute, including F. M. Bricker.

After the war, the head of the department was Emmanuil Ya. Sterkin (1945-1952), who was a man of unusual lecturing abilities. A lot of attention paid to equipping the department. Under the guidance of E. Ya. Sterkin, the department staff dealt with issues of carbohydrate metabolism disorders in liver pathology, diabetes, heart failure, etc. The department staff prepared two Ph.D. theses during this time.

In 1952, due to leaving the departure of Professor E. Ya. Sterkin, Ivan N. Sukhetoply (1952-1968) was elected to the position of head of the department. First, the department staff investigated the involvement of the nervous system in the body's reactions to the action of various physiological and pathogenic factors. Then the involvement of the nervous system in the tumor process was studied. The results of the work were presented at the second congress of oncologists and the third republican congress of radiologists of the Ukrainian SSR.

At the same time, the department was engaged in the organization of special spectrographic laboratories of chemical blastomogenic substances and tumor chemotherapy in the Central Scientific Research Laboratory. During 1952-1965, the staff of the department carried out 38 scientific works published in various scientific journals and collections. The department provided assistance and created the conditions for the implementation of two doctoral and five master's theses.

In 1968, Ivan. N. Sukhetoply suddenly died of heart attack.

During the leadership of Valentin V. Luk'yanets (1969–1977), the department suffered a personnel crisis, due to which the planning and execution of dissertational works by assistants was strengthened. In addition, the department conducted intense scientific and methodological work, which was to improve the methodology of lectures and practical classes and more detailed programming of educational material. The research work of the department staff was devoted to the pathological physiology of the tumor process. The carcinogenic substances of the environment, metabolic factors during tumor growth, the relationship of regulatory systems and tumor growth were studied. In the works of V. V. Luk'yanets, the problem of neuro-neoplastic interactions was developed. V. V. Lukianets was the head of six Ph.D. theses. The completed and successfully defended works contributed to the development of new relevant areas of tumor pathology research. During this period, the staff of the department published about 120 scientific works, received11 certificates for rationalization offers and a copyright certificate. Department staff did reports at 6 All-Union congresses and at 9 republican congresses.

During the management of the department by Professor Oleg I. Sukmansky (1977-1997), the direction of scientific research changed. The department developed the issue of neuro trophism and the pathogenesis of neurogenic dystrophies. To solve the problem of the pathogenesis of neurogenic dystrophies, the efforts of the members of the Department of Pathophysiology, Normal Physiology and Biochemistry were combined. To carry out research in this direction the department acquired a fluorescent microscope “Lyumam”, a polygraph, a rheograph, etc. Methods of polarographic determination of oxygen tension in tissues, rheography, cytospectrophotometry and radioautography were mastered and introduced. Work was also carried out to improve the teaching of pathological physiology: a lecture course was reviewed and updated, lecture demonstrations of experiments and films were introduced, and a library of lectures was created.  The number of microscopes, counting chambers and laboratory glassware was doubled. Renew textbooks and teaching aids were created. A. I. Sukmansky had written the chapters "Violation of water-salt metabolism" and "Pathological physiology of digestion" for a textbook edited by M. N. Zayk.

In 1977-1997, under the guidance of Professor A. I. Sukmansky five doctoral and six master's theses were completed. The department published more than 180 scientific papers, received 3 copyright certificates.

In 1992, the staff of the department organized and held the Ukrainian conference of pathophysiologists

From 1985 to 1989, written exams, test and rector controls were introduced, case studies were developed. In the future, in connection with the establishment of an independent Ukraine, a lot of effort was put into adapting educational materials in the Ukrainian language.

In 1997, Professor A. I. Sukmansky retired and went to Odessa, where he still teaches at Odessa Medical University. The Department of Pathological Physiology at that time was merged with the Department of Normal Physiology under the guidance of Professor Peter A. Nerush.

But already in 1999, the department was divided under the guidance of Professor Viktor Vladimirovich Koldunov (1999-2010), the author of 243 scientific works, 2 inventions, 8 rationalization proposals, an information letter. At that time, two manuals for practical training of students with the classification of the CMC of the Ministry of Health of Ukraine and two collections of tests Krok-1, a guide to general pathophysiology and pathophysiology of organs and systems were published. The main scientific direction of the department remained the study of neurogenic dystrophies. Together with the Department of Normal Physiology in 2001-2004, the budget research work "Study of the mechanisms of the nervous system under the action of extreme factors."

During 2011-2012, Associate Professor Gennady Vladimirovich Dovgal headed the department. He began updating the material (information boards and visual teaching materials) and methodological support for the department, headed the department. During this time, nine scientific and three scientific and methodical articles were published.

Since 2012 and until now the head of the department is Professor Marina A. Dovgal. Under her leadership, the preparation of a new manual for the control of students' knowledge in the preparation of modules has begun.

Professor Julia V. Silkina performed duties as the head of the department from 2013 to 2016. During this period, there were updated methodological developments for practical studies, a base of tests, a computer class, and lecture material. During this period, 45 articles were published. Together with the staff of the department, the training stands were updated.

Today, the department has a cohesive and creative team of scientists and teachers who annually publish methodological and scientific articles, participate in international and national conferences, perform public duties and assignments, play sports and learn foreign languages!